Job Title: Director/Senior Director, In Vivo Pharmacology - Oligonucleotide Sciences

Location: 200 Cambridge Park Drive, Cambridge, MA

Position Overview: GSK is seeking an experienced Director or Senior Director of In Vivo Pharmacology to join our Oligonucleotide Sciences research team. This leadership role offers an exciting opportunity to drive the design and execution of in vivo strategies for multiple discovery and platform projects. The successful candidate will report to the Head of Oligonucleotide Sciences, interface across the organization, and may have the opportunity to build and lead a small team.

Key Responsibilities:

• Act as the single point of accountability for the design and execution of in vivo pharmacology strategies for all discovery and platform capability projects within the Oligonucleotide Sciences team.
• Interface with cross-functional teams, including in vitro biology, chemistry, informatics, biostatistics, disease biology, DMPK and non-clinical safety, to design effective and robust PK/PD studies in line with project requirements.
• Build and maintain effective relationships with leading CROs, ensuring timely delivery of high-quality study data.
• Work with rodent (including transgenics where appropriate) and non-human primate (NHP) models to generate high-quality data supporting project goals while adhering to GSK’s study design, data integrity, and animal welfare policies.
• Analyze, interpret, and present data to internal stakeholders, ensuring clear communication of study outcomes and recommendations.
• Remain current with scientific and technological advancements in the field of oligonucleotide therapeutics and in vivo pharmacology.
• Potentially build and lead a small team of in vivo pharmacologists to support expanding research needs.

Minimum Qualifications:

• PhD in Pharmacology, Biology, or a related field.
• At least 10 years of experience in the design and execution of in vivo PK/PD studies.
• Experience in the field of oligonucleotide therapeutics, including contemporary routes of administration such as subcutaneous, inhaled, and intrathecal.
• Ability to work independently and manage multiple projects simultaneously.
• Ability to collaborate with multidisciplinary teams, including in vitro biology, chemistry, biostatistics, and non-clinical safety.
• Demonstrable leadership capabilities with experience working in a complex matrix environment.
• Demonstrable analytical, problem-solving, and communication skills.
• Experience working with rodent and non-human primate (NHP) models.
• Ability and excitement to contribute to the development and success of a new and growing department.

Preferred Qualifications:

• Experience working in a pharmaceutical or biotechnology research environment.
• Record of high-impact publication in peer reviewed journals.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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