Vertex Pharmaceuticals
Senior Principal Engineer - Data and AI Platforms
Boston, MA
Aug 5, 2025
Full-time
Full Job Description

Job Description

We are seeking a dedicated Senior Principal Engineer with a passion for data engineering, to lead and manage our critical Data and Artificial Intelligence (AI) Platform. As part of the Data & Software Engineering (DSE) Team, you will be responsible for developing and maintain the infrastructure and tools required for the deployment, monitoring, and continuous improvement of data and AI platforms.

You will work closely with data engineers and software engineers to scale the Vertex Data Platform (VDP), which is Vertex’s cutting-edge technology ecosystem for Data Engineering, Data Science, and Advanced Analytics. Using the VDP, you will help ensure the seamless development, operations, and monitoring experience for data engineers, software engineers, and end users. You will help Vertex scale and support data products across our organization to fuel insights & innovation. You will partner with data engineers, data scientists, and operations teams to build, deploy, manage and scale modern data and AI platforms – helping provide teams with best practices, guidance, and support.

Vertex Pharmaceuticals is in a transformational period where we are accelerating our capabilities, technologies, and data to augment our scientific mission, enable Vertex to grow in scale, and continue to be on the forefront of science, medicine, and technology. As part of this effort, it is critical to ensure that the Vertex’s data and AI platform continues to accelerate and enable our data engineers to drive innovation and insight.

Key Responsibilities:

  • Platform management - Manage, maintain, and improve Vertex’s core data platform with a focus on security, DevOps, and enabling best practices for users to design, implement, and manage end-to-end data pipelines
  • Technology expert – Accountable for developing, deploying, & maintaining Vertex Data Platform components that enable & support the full development and deployment cycle for advanced Data Engineering and Artificial Intelligence solutions
  • Delivery management – Estimate, architect, and execute on delivery of critical projects & solutions, in partnership with the DSE leadership team, that support and enable data engineers
  • Operations Management – Manage & partner with a team of Data Engineers to maintain the Vertex Data Platform. Troubleshoot and resolve issues related to data product deployment, execution, and performance
  • Innovation champion - Advocate for process enhancements and opportunities to improve our Data Engineering capabilities. Partner closely with Director, Data Platforms for defining, architecture and designing data platform components. Collaborate with data scientists and data engineers to integrate best practices into the development lifecycle

Qualifications:

  • 10+ years of experience working as a Software Engineer, DevOps Engineer, or Data Engineer within a production ecosystem
  • 5+ years working in Principal Engineering role leveraging Snowflake, AWS, or equivalent cloud data platforms
  • Demonstrated experience with model pipeline technologies like Astronomer / Airflow
  • Demonstrated experience in developing (or supporting) Data engineering solutions leveraging DBT cloud
  • Demonstrated experience in data integration solutions like Fivetran
  • Strong experience monitoring and optimizing the security and performance of modern data platforms
  • Experience automating model training, validation, and deployment processes to enhance efficiency and reproducibility
  • Demonstrated experience working in agile environments (5+ years)
  • Demonstrated ability to work independently and manage multiple projects that require collaboration across functional areas.
  • Skillful, collaborative team player able to develop rapport and credibility with stakeholders.
  • Demonstrated ability and willingness to teach, engage and support others as they learn new technologies and concepts.
  • Enthusiasm for and the ability to quickly learn new technologies and tackle difficult problems.
  • Strong presentation, verbal, and written communication skills
  • Working knowledge of key workflow tools, including JIRA and Confluence

Pay Range:

$164,300 - $246,400

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

Remote-Eligible

Flex Eligibility Status:

In this Remote-Eligible role, you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

PDN-9f8ef297-0a2a-427e-bbc1-e22977ddc198
Job Information
Job Category:
Engineering
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Senior Principal Engineer - Data and AI Platforms
Vertex Pharmaceuticals
Boston, MA
Aug 5, 2025
Full-time
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