Description

A key scientific leader of the Immunology and Respiratory Translational Biology Group, the Principal/Sr. Principal Scientist is responsible for establishing the scientific know-how and experimental approach in rheumatology to support the positioning of discovery molecules within this disease space. As a laboratory leader, the incumbent will direct a team of scientists to develop and apply complex in vitro translational assays across discovery and development projects. Candidates must have a strong knowledge in immunology with drug discovery experience in rheumatological diseases and a proven track record of productivity both independently (with minimal supervision) and within a team setting in a matrix and collaborative environment.

Duties & Responsibilities

• Lead and guide positioning of molecules in the disease area of Rheumatology by generating a scientific translational data package to support disease selection. Serve as the rheumatology disease area expert in Research by demonstrating up-to-date knowledge of rheumatological diseases including pathogenesis, standard of care, unmet need, and using this knowledge as the basis for developing translational assay systems.
• Independently proposes, design and performs scientific experiments with a predefined goal including developing new methodologies, protocols and or test procedures that contribute to core group/research goals and reflect expert knowledge; Direct and oversee experimental design and results of technicians and junior level scientists
• Assumes leadership role for either project teams and/or acts as a translational biology representative on multiple project teams and contributes to overall program goals
• Prepares clear technical reports, publications and oral presentations. Independently communicate results in the form of reports and/ or presentations; Deliver updates to senior level management in context of overall project goals
• Build strong connections with external key opinion leaders in the field of rheumatology, Incorporate feedback and scientific insights into projects and experimental plans. Remain abreast of scientific literature.
• Work collaboratively within department, and across the Innovation Unit, including with Translational Medicine colleagues and Medicine. Assumes responsibility for direct reports as needed including recruiting, managing, mentoring and developing scientific staff
• Complies with all applicable regulations; Ensures that work performed in area of responsibility is conducted in a safe and compliant manner; Maintains proper records in accordance with SOPs and policies
• Contributes to departmental administration; Demonstrates fiscal responsibility with respect to cost of experiments, technology, external collaborations, and travel

Requirements

Requirements for Both Levels:

• Appropriate level of understanding of applicable regulations
• Ability to communicate effectively both orally and in writing in an interdisciplinary environment
• Previous supervisory experience preferred
• A demonstrated track record of independent research and peer-reviewed publications in areas of immunology. Comprehensive knowledge of Rheumatologic diseases, including understanding of the T and B cell biology and interaction to other components of the tissue microenvironment.
• Strong understanding of immunology, with robust in vitro experimental skills. Prior hands-on experience with developing novel in vitro complex cellular models to assess the effects of novel therapeutic concepts. Expertise in establishing Rheumatologic-relevant culture systems is a plus.
• Strong problem-solving skills and sound judgment to accelerate strategic and project decision-making. 
• Team player with strong verbal, presentation, and written communication skills, with the ability to propose, articulate, evaluate and defend scientific ideas and data.
• Ability to mentor, develop and lead a group of scientists to deliver high quality data to contribute to overall program goals. Be accountable for the effective performance of the individuals.
• The ability to prioritize responsibility and be comfortable with changing direction and/or priorities.

Principal Scientist:

• Ph.D. Degree or equivalent in relevant field with 5+ years related experience in a related field or equivalent

Sr. Principal Scientist:

• Ph.D. Degree or equivalent in relevant field with 7+ years experience in addition to experience in lab management

Compensation:

This position, Principal Scientist, offers a base salary typically between$140,000.00 and $222,000.00. The position may be eligible for a role specific variable or performance based bonus and or other compensation elements.For an overview of our benefits please click here.

Desired Skills, Experience and Abilities